Essential oil contents of seeds of Wonderful kola, African walnut and Guinea plum and their potentials on hyperlipidemic Wistar rats were investigated. Diet-induced type II A hyperlipidemia in rat model was achieved by oral administration of egg yolk and groundnut oil formulation for two weeks. Rats fed normal diet constituted the negative control for comparison. The chromatogram obtained using GC/MS for Wonderful kola revealed the presence of fifteen compounds. The major compound in the harvested essential oil was 1, 2- benzenedicarboxylic acid mono (2-ethylhexyl) ester (74.88%). Those for African walnut seeds revealed the presence of ten compounds which amounted to 86.2 % of the total oil composition. The major abundant compounds in the essential oil was Diethyl Phthalate (76.94%) and results from the essential oil composition of Guinea plum showed the presence of fifteen  compounds which amounted to 100% of the total oil composition. The compounds in the essential oil were 1,2- benzenedicarboxylic acid, diisooctyl ester (34.65%), diethyl phthalate (14.95%), cyclopentaneacetic acid, ethenyl ester (10.1 %), fumaric acid, 3-methylbut-3-enyl tridecyl ester, (7.79 %), Phytol (6.7%) 2,4- and Nonadienal, (E, E) (4.33%). In comparison to control, administration of tried samples markedly lowered weight gain by animals, total cholesterol, triglycerides, AST, ALT ALP, plasma contents of LDL and atherogenic indices in a dose dependent fashion. Their administration also produced significantly higher (p&lt;0.05) plasma HDL cholesterol levels indicating recovery. These results showed the nutraceutical potentials of these three seeds and suggest their use in management of hyperlipidemia in the order. Similarly, abundance of 1, 2- benzenedicarboxylic acid mono (2-ethylhexyl) ester in harvested essential oil from Wonderful kola suggests their possible use in the management of cancer given their established potentials. However, heavy presence of phthalate esters in harvested essential oil from African Walnut suggest possible varied toxicity on consumption and may portend danger.<br/>

Essential oil content of the seeds of Wonderful kola, African walnut and Guinea plum and their potentials on hyperlipidemic male Wistar rats

255th National Meeting (2018)

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