Herbicides (glyphosate, glufosinate, N-acetyl glufosinate, ethephon, fosetyl-Al, and maleic hydrazine) and their metabolites (N-acetyl AMPA, AMPA, HEPA, 3-MMPA), are increasingly a public concern in food, and a regulatory concern under the classification of polar pesticides. Ion chromatography (IC), designed for the determination of ionic compounds in a variety of samples, including food, is better suited for separating these compounds than other chromatography methods. Additionally, IC is a direct determination method unlike GC which requires labor intensive and costly derivatization. To provide accurate reporting when testing herbicides and pesticides, molecular identification and confirmation are critical. High resolution accurate-mass mass spectrometry (HRAM MS) provides sensitivity to single part per billion due to the low chemical noise provided by the IC separation and the high resolving capabilities of the Thermo Scientific Orbitrap MS. Disinfection byproducts and perchlorate contaminations are also contamination concerns in food, but typically require separate determinations. Here we combine the determinations of polar pesticides, perchlorate, and disinfection byproducts in diluted fruit juices and beer samples into one method. All analytes are separated by IC on a 2 x 150 mm anion-exchange column within a 15 min run and detected serially with suppressed conductivity and HRAM MS in full scan from 60–750 m/z and in SIM mode.

Determination of ionic herbicides in beverages and fruit samples using ion chromatography coupled with high resolution accurate mass spectrometry

255th National Meeting (2018)

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