Precision health care is poised to transform what we know about staying healthy, treating diseases and how health care is delivered. The foundation of precision health care is the genomic makeup of each individuals. Scientific and technological advances in recent years have made it possible to sequence a human genome in about one day and at a relatively low cost of a few thousands of US dollars. However, accurate, rapid and direct sequencing of long deoxyribonucleic acid (DNA) sequences remains elusive. In this talk, I will give an overview of our efforts to develop nanometer-scale silicon chips (fluidic DNA nanochips) for accurate, rapid and direct sequencing of long DNA sequences using the current integrated circuit (IC) manufacturing infrastructure. I will present fabrication of nanostructured fluidic devices of critical dimensions less than 10 nm using either optical lithography or a combination of optical lithography and electron-beam lithography in a 200 mm wafer nanofabrication line. Detecting and manipulating long single DNA biopolymers with these fluidic nanochips will be discussed.<br/>

Detecting and manipulating single DNA biopolymers with fluidic nanochips

255th National Meeting (2018)

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