Lipid extracts are an excellent choice of model biomembrane; however at present, there are no commercially available lipid extracts or computational models that mimic microbial membranes containing the branched-chain fatty acids found in many pathogenic and industrially relevant bacteria. We advance the extract of Bacillus subtilis as a standard model for these diverse systems. The development and validation of this model was recently published, providing a detailed experimental description and equilibrated atomistic bilayer model. The creation of this model represents an advance which enables more realistic simulations and experiments on bacterial membranes and reconstituted bacterial membrane proteins that might be incorporated in this membrane model. The equlibrated version of the atomistic membrane model are available as supplementary informtion to that Letter, at http://cmb.ornl.gov/members/cheng, or NickelsLab.com.

Bacillus subtilis lipid extract, A branched-chain fatty acid model membrane

255th National Meeting (2018)

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