Polymeric materials have made a tremendous impact on a multitude of biomedical applications. For example, the development of polymer excipients can improve the solubility and bioavailability of intractable drugs. Also, nucleic acid delivery vehicles have promise to promote selective genome editing. Despite diverse function, the chemistry to create the materials in these structures is often similar and should be readily tunable for activity in each specific application while remaining biologically benign. Indeed, the chemical and physical properties of polymers containing biologically-friendly and functional monomers can be tuned based on chemistry, sequence, and composition to yield diverse function and properties. Herein, the design and development of tailored block polymers that contain hydrophilic, cationic, and hydrophobic domains will be presented that serve as attractive shape and size-regulated vehicles for the delivery of drugs, DNA, RNA, and Cas9 protein. Specific arrangement and length of the blocks offer tuning of self-assembled morphologies such as micelles and worm-like micelles. Hierarchical complexation of these structures with biomolecules has been studied in detail and their application in the improvement of oral pharmaceutical bioavailability and as novel vehicles for genome editing applications will be presented.

Amphiphilic multiblock polymers form controlled assemblies to promote oral drug delivery and cellular genome editing

255th National Meeting (2018)

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