Iron oxide nanoparticles have had a profound impact in medical diagnostic, imaging, and drug delivery techniques. Their potential to reduce the invasiveness of many procedures while improving the accuracy and sensitivity have been well noted. Their effectiveness is determined significantly by how well the particles are stabilized in aqueous solution. To do this, organic ligands are prepared that coat the nanoparticle in order to (1) aid in their hydrophilicity, (2) prevent aggregation which can lead to an embolus formation in the bloodstream, and (3) have a variable chain that can bind to drugs and help deliver them to specific tissues in the body. Novel synthesis of 2-hydroxyisophthalic acid has been used as the ligand’s coordination moiety that attaches directly to the nanoparticle’s surface. This project’s focus is on synthesis of its functional derivatives with chain substituent that is long enough to provide hydrophilic properties without depressing the nanoparticle’s magnetic efficiency. To this end, oligomeric ethylene oxide and glycerol derivatives are used with various terminal groups that will provide a bioconjugation linkage.

Synthesis of stabilizing ligands for metal oxide nanoparticles

255th National Meeting (2018)

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