Nanomaterials are defined as materials with at least one external dimension in size range of approximately 1-100 nm. Nanomaterials are versatile materials in various fields of science, ranging from material science, energy, to medicine. Knowledge on the interactions of nanomaterials with different biomolecules is limited hence this study was conducted. The interaction of nanoceramics (aluminum oxide, silicon oxide, titanium oxide and zinc oxide) with human serum albumin (HSA), the most abundant protein constituent of blood plasma, was investigated by various spectroscopic methods (absorbance, fluorescence, and circular dichroism). Results showed aluminum oxide significant changes in terms of reduced absorbance and emission and change in the CD profile in comparison to the other nanoceramics. Absorbance reduction in samples with silicon oxide was also observed. In addition to the reduction of emission intensity in all samples with metal oxides, a peak was observed to arise around 420 nm for zinc oxide and 410 nm for aluminum oxide and silicon oxide when more amount of nanomaterials were added.

Binding interaction of nanoceramics (metal oxides) with human serum

255th National Meeting (2018)

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