Candida albicans cell wall mannans consisting of β-(1→2)-linked oligomannosides are known to possess immunostimulatory properties. In recent work, we have shown that synthetically constructed mimicks based on fully acetylated, trivalent β-(1→2) linked mannobiose glycoclusters function as promising immunostimulants in vitro and in acute and chronic asthma mouse models also in vivo. These compounds could find application, for example, in allergen specific immunotherapy. Here we show that the same glycocluster compounds also inhibit the growth of melanoma tumors in mice with activity level similar to PD-1 immune checkpoint inhibitor used as reference in the study. With the rapidly increasing number of melanoma patients globally, new immuno-oncological treatmens are actively sought. Here, carbohydrate derived therapeutics could gain advantage being of lower overall toxicity, providing high activities combined with better safety and side effect profiles.

Immunostimulatory mannose derived glycoclusters as potential cancer therapeutics

255th National Meeting (2018)

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