Pyrrolizidine alkaloids (PA’s) are potentially toxic, naturally occurring secondary products typically found in the plant family Boraginaceae. As a part of continuing alkaloid analysis of the family Boraginaceae, the Eurasian plant Buglossoides purpurocaerulea was analyzed to establish a GC-MS PA profile. Preliminary findings indicate the presence of both saturated and unsaturated PA’s along with potential isomerization at the 1, 7, and 8 positions within the pyrrolizidine bicyclic ring structure. Chromatographic based isolation of the major compounds will result in the NMR elucidation of the structures.

Structural elucidation of pyrrolizidine alkaloids from Buglossoides purpurocaerulea

255th National Meeting (2018)

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