The target compound has three major parts, the naphthalimide core with tail, a linker, and the target drug. The naphthalimide core is a photoactive molecule. When exposed to light detaches from the linker-drug portion of the compound. The freed end of the linker then binds with tissue in the body, keeping the drug in the localized region of the body. A hydrolysis reaction then occurs breaking the bond between the linker and the drug. Our research focused on the synthesis of target compound. There were two reactions schemes used during this research. The original scheme followed steps to synthesize the naphthalimide core with the tail and linker portion of the compound first, then it is coupled with the target drug. The second scheme, or modified scheme, was developed during this project to more effectively synthesize the target product. In the modified scheme, first half of the linker is attached to the naphthalimide core with the tail, then the other half is attached to the target drug, and finally the two halves of the linker are attached.

Synthesis and coupling schemes of naphthalimide compounds with target drugs

255th National Meeting (2018)

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