The stability of drugs is an important, yet currently under-researched, aspect of analytical chemistry. Over the last decade, new psychoactive drugs have appeared on the drug market, many of which have not been fully evaluated. One such drug is AH-7921. The novel opioid AH-7921 was found stable over a period of 60 days in methanol and acetonitrile at room temperature (25 °C), in the refrigerator (4 °C), and in the freezer (–20 °C). However, human consumption of AH-7921 has decreased in recent years due to negative such side effects as nausea. This research will determine the stability of the internal standard used, U-47700. U-47700 usage has greatly increased in the last year and has led to many fatalities. This stability study will be carried out using the same parameters as AH-7921. Samples of U-47700 will be prepared in both methanol and acetonitrile and then stored for 0, 3, 7, 14, 30, and 60 days. Stability will be assessed by addition of fresh internal standard to each sample prior to analysis by gas chromatography mass spectroscopy (GC-MS). Samples will be analyzed in triplicate and compared to a calibration curve to determine the concentration of the opioid remaining in each solvent. GC-MS analysis will be carried out in full scan mode so that production of metabolites may be monitored.

Stability of AH-7921 and U-47700 in polar organic solvents

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.