Indole/indazole and quinolone sub-units are found in numerous biologically active compounds; many of which are known to exhibit anticancer, antibiotic, and/or antimicrobial activity. Therefore, a research project with the overriding goal of exploring the anticancer/antibiotic/antimicrobial activity of compounds that contain both the indole/indazole and quinolone sub-units was developed. The project is highly amendable to being divided into sub-projects that focus on different locations of indole/indazole and quinolone sub-unit connectivity, with each individual early stage sub-project will focusing on the synthesis of a handful of analogues that share the same indole/indazole and quinolone sub-unit connectivity. Our specific sub-project focused on synthesizing indole-quinolone and indazole-quinolone analogues with sub-unit connectivity located at the N1 of the indole/indazole sub-unit and both the C6 and C8 of the quinolone sub-unit, which we synthesized via use of either an ortho- or para-disubstituted precursor. We successfully synthesized a handful of analogues with both the N1-C6 and N1-C8 sub-unit connectivity and our research collaborators are conducting in vitro biological studies testing the anticancer/antibiotic/antimicrobial activity of each compound.

Synthesis of indolyl/indazolyl (N1 substituted) quinolones (C6 and C8 substituted) for study as possible anticancer/antibiotic/antimicrobial agents: Desired cyclized product or uncyclized intermediate?

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.