As the active ingredient in some osteoporosis treatments, strontium has a demonstrated ability to balance the rates of bone growth and resorption. Unfortunately, orally administered strontium drugs have systemic side effects that limit their use. Strontium-doped hydroxyapatite (Sr-nHAps) offers an alternative, non-toxic method of delivering low concentrations of Sr2+. Using a hydrothermal method, we synthesized Sr-nHAps with a range of Ca:Sr ratios and characterized these materials by SEM, EDS, and P-XRD. To investigate the rate at which Sr2+ leaches out of the particles, the Sr-nHAps were shaken in PBS as a biological mimic. The amount of Sr2+ that leached into the buffer was determined at various time points using ICP-OES. Further ,we have used EDS and P-XRD and to examine the compositional and structural changes respectively in the hydroxyapatite lattice that occur due to Sr2+ leaching.

Synthesis and leaching of strontium-doped hydroxyapatite

255th National Meeting (2018)

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