Dietary fiber polymers, like cellulose, present positive physiological effects in the gastrointestinal tract. They are known to lower blood cholesterol levels, a risk factor associated with cardiovascular disease (CVD). One of the mechanisms behind lowering blood cholesterol levels is fiber’s ability to interfere with lipid digestion and absorption through interactions with bile salts (BS). BS, biosurfactants synthesized from cholesterol, play critical roles in lipid digestion; one of which is they adsorb onto lipid droplet surfaces, which initiates the enzymatic hydrolysis of triglycerides (lipolysis). Cellulose derivatives may delay the rate of lipolysis by adsorbing onto lipid droplet surfaces, thus hindering BS adsorption to the interface. Cellulose derivatives may also bind to BS in the duodenum, causing BS to be sequestered and excreted, resulting in more BS being synthesized from blood cholesterol. However, the precise nature of these physiological mechanisms remains unclear and cellulose’s efficacy to interfere with lipid digestion depends on the cellulose type and BS concentration. The objective of this study is to design novel cellulosic nanoparticles that have greater functionality than commercial cellulose derivatives to control BS binding/adsorption at high BS physiological concentrations and at minimum cellulose concentrations. Amphiphilic derivatives of hydroxypropyl cellulose (HPC), with a carboxyl or lithocholic acid functional group, have been prepared through novel, mild, versatile olefin cross-metathesis chemistry. Structural differences in these selected amphiphiles will allow us elucidate the key structure-property-performance relationships of the novel cellulosic nanoparticles. Techniques such as QCM-D and SPR have been used to examine the surface interactions and binding ability of the nanoparticles and endogenous BS at the interface or in the bulk. These findings will provide valuable information on how cellulose can be tailored and exploited into both novel food and pharmacological matrices to control CVD.<br/>

Characterizing interactions between novel amphiphilic cellulose derivatives and bile salts using quartz crystal microbalance with dissipation monitoring (QCM-D) and surface plasmon resonance (SPR)

255th National Meeting (2018)

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