Sudan I, 1-phenylazo-2-naphthol (C.I. Solvent Yellow 14 and Solvent Range R) is a synthetic azo dye which is used as a coloring agent. Its use in food products is illegal, as it is classified as a mutagen, however it has frequently been found in food products such as chili powder, paprika, curry powder, saffron, and palm oil (M. Coulet, Food and Chemical Toxicology 48 (2010) S106–S111 ). Between 2003 and 2005, over 600 food products containing Sudan dyes were recalled in the UK. The international agency for research on cancer (IARC) has found limited experimental evidence for carcinogenicity and there is no adequate data in humans. NTP experimental study tests have yields mixed results. We will report computational modeling and analysis of Sudan dye-DNA interactions and interactions with DNA repair enzymes to shed some light on mechanisms of Sudan dye genotoxicity.

Computational analysis towards understanding food dye and coloring agent genotoxicity

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.