Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) have been shown to exert anti-cancer effects on multiple types of cancer cells in vitro. Several different mechanisms have been proposed such as apoptosis induction, inhibition of angiogenesis and tumor cell migration. Preliminary data using THC and CBD demonstrate an overall dose-dependent growth inhibition of breast cancer cells in both 4T1 and MCF-7 cell lines and an induced proliferation at higher doses. The molecular mechanism by which tumor growth is inhibited will be assessed with an initial test on both 4T1 and MCF7 cell lines. Results with pancreatic, colon, brain, lung and skin, cancer cells will be reported.

Cannabinoids as anti-cancer agents: What's really going on?

255th National Meeting (2018)

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