The use of perfusion in the seed train to increase volumetric productivity increases facility yield and flexibility. Here we use multiple case studies to show the optimization of the process to match the facility fit, adjust to program needs, and generate a platform process. Finally we show the transfer of the bench scale process to a validated manufacturing process with significant increase in volumetric productivity.

Development and implementation of perfusion N-1 for mammalian cell culture to enhance process productivity

255th National Meeting (2018)

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