<br/>The enzyme lysyl oxidase (LOX) has been reported to be involved in the metastasis of malignant growth of cancerous cells. β-Aminopropionitrile (BAPN) has long been considered an effective inhibitor of the enzyme, however, it can produce toxic side products inside the body. Previous work has found that the addition of benzyl derivatives to BAPN have been effective in increasing the cell mortality of cancerous cells. We report the preparation of new hydroxybenzyl and pyridinylmethyl BAPN derivatives.

Synthesis of phenol and pyridine containing LOX inhibitors

255th National Meeting (2018)

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