Sensitive and specific chiral analysis has long been a challenging problem in the world of analytical chemistry. The traditional techniques of circular dichroism and vibrational circular dichroism require high sample densities because of their weak signals, which is an issue in some applications. A highly specific chiral analyzer has been demonstrated both in pure samples and in mixtures, using three-wave mixing in the 12-18 GHz frequency regime. This technique results in assignment of absolute stereochemical configuration of molecules, which typically requires optical techniques or NMR shift reagents, while using very little sample at low gas-phase density. We will present application of this technique to both pure samples and mixtures of chiral isotopologues of primary alcohols.

Sensitive chiral analysis of chiral isotopologues via microwave three-wave mixing

255th National Meeting (2018)

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