There is growing interest in Zr-89 as a PET-imaging isotope, due to its desirable half-life of 78.4 hours and the potential for strong complexation. A number of studies utilize desferrioxamine B (DFO) as the Zr(IV) chelator, however, stability concerns are an issue because DFO provides only six coordination sites. We are therefore pursuing DFO derivatives that are eight-coordinate to increase Zr(IV) formation constant and decrease the possibilities of demetallation. In this research, we present the synthesis, Zr(IV) complexation and aqueous speciation of a bifunctional octadentate DFO derivative.

Investigation of <sup>89</sup>Zr<sup>+4</sup> chelation for positron emission tomography

255th National Meeting (2018)

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Investigation of 89Zr+4 chelation for positron emission tomography

Investigation of ⁸⁹Zr⁺⁴ chelation for positron emission tomography