Masoprocol, also known as nordihydroguaiaretic acid, is an antineoplastic drug that inhibits skin growths and holds anti-inflammatory properties. Currently, methods for the development of skin treatment drugs that are ecofriendly, low cost, convenient and sustainable are imperative as the demand for such treatment increases. In this work, we aim to describe the synthesis of a cross-linked gold nanoparticle-polymer network, in the form of a protective hydrogel containing nordihydroguaiaretic acid extracted from the plant <i>Larrea tridentata</i>. The hydrogel was prepared via polymerization of acrylamide, polyethylene glycol dimethacrylate, polyvinyl alcohol, and lithium-phenyl-2,4,6-trimethylbenzoylphosphinate. Nordihydroguaiaretic acid-capped gold nanoparticles were synthesized and incorporated into the hydrogel to produce a wound dressing. The results demonstrate that metallic gold nanoparticles can readily integrate into a cross-linked polymer and function as a drug delivery system for the topical treatment of skin lesions.

Green synthesis of a cross-linked polymerized hydrogel containing NDHGA-capped gold nanoparticles for skin lesion treatment

255th National Meeting (2018)

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