Bromination of 2-methyl-3-phenylpyrazine afforded 2-bromomethyl-3-phenylpyrazine in good yield. The product was treated under two different sets of reaction conditions with terminal alkynes to yield 1<i>H</i>-1,2,3-triazole derivatives. Typically the desired products were obtained in acceptable yield along with minor side products. Purification was accomplished using flash chromatography. Purified products were characterized using NMR spectroscopy and FTIR spectroscopy.

Triazole derivatives from 2-bromomethyl-3-phenylpyrazine

255th National Meeting (2018)

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