Reaction of tetrafluoropyridyl azide with terminal alkynes under Sharpless/Meldal conditions (click chemistry) afforded triazole derivatives containing the 2,3,5,6-tetrafluoropyridine moiety. The triazole derivatives were isolated and purified using flash chromatography. The purified triazoles were gave nucleophilic substitution to produce brominated triazoles, which were also purified using flash chromatography. These compounds were propargylated via Williamson ether synthesis to produce alkynyltriazoles. All products were solids and each reaction gave good yields and recoveries. The purified products were characterized using <sup>1</sup>H NMR and infrared spectroscopy.

Synthesis of perfluoropyridyl-1<i>H</i>-1,2,3-triazole derivatives

255th National Meeting (2018)

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Synthesis of perfluoropyridyl-1H-1,2,3-triazole derivatives