Isoxazole derivatives were prepared by Cu(I)-catalyzed cycloaddition of organic nitrile oxides and alkynes in one-pot syntheses. The nitrile oxide intermediates were formed from aryl aldoximes with <i>N</i>-chlorosuccinimide at low heat with light. Reactions were carried out as one-pot syntheses where all reagents were left to react to form products in a single step. Crude products were extracted with ethyl acetate and submitted to flash column chromatography for purification, giving the final products, which were characterized using NMR and infrared spectroscopy.

Synthesis of isoxazoles via copper(I) catalysis with <i>N</i>-chlorosuccinimide

255th National Meeting (2018)

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Synthesis of isoxazoles via copper(I) catalysis with N-chlorosuccinimide