Studies on the heteroarylation of olefins have been previously reported.  Our lab is currently investigating an intramolecular variant that results in the rearrangement of an aromatic group with certain substitution patterns. In an attempt to study the mechanism, four different 2,2-diaryl-4-pentonic acids were synthesized, purified, and reacted with Pd(TFA)<sub>2</sub> to study the substituent effects on the reaction outcome. These products were identified as the major products of such rearrangements and were purified in acceptable yields. Additional studies to determine the stereochemical outcome of the reaction were conducted to further investigate the mechanism of this novel reaction.<br/>

Mechanistic investigations into a novel palladium-catalyzed oxidative difunctionalization reaction

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.