Peroxisome proliferator-activated receptor δ (PPARδ) plays a pivotal role in obesity-related diseases associated with lipid metabolism and is involved in the differentiation and anti-inflammatory effects of neuronal cells. Peroxisome Proliferator-Activated Receptor δ (PPARδ) has recently come into the focus as a re-emerging drug target for the treatment of associated diseases such as metabolic syndrome as its activation alters glucose and lipid metabolism through a transcriptional regulation and results in beneficial pharmacological actions, typically an exercise mimic. We synthesized novel PPARδ ligands and an efficient synthetic route to these analogs was also developed. Some selective PPARδ ligands showed good bioavailability and in vivo efficacy. These results suggest that our novel PPAR δ agonists could be promising candidates for inflammation and metabolic diseases.<br/>

Design and synthesis of novel peroxisome proliferator-activated receptor δ agonists

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.