Current engineered bone scaffolds are fabricated using synthetic and natural polymers. These biomaterials exhibit excellent biocompatibility and designed scaffolds intent to fully meet physico-mechanical properties like natural bone. In this research, we prepared cellulose acetate (CA) nanofibers to use as a fibrous scaffold for bone tissue regeneration. Its large nanostructured topography, that act as an artificial extracellular matrix, desired biocompatibility and low cost of production make cellulose a suitable biomaterial for this end. To improve mechanical strength of CA scaffolds, incorporation of well-dispersed nanodiamonds (ND) have been addressed as a promising nanofillers. To avoid poor dispersion of nanodiamonds in the CA matrix, the novel salt-assisted ultrasonic deaggregation (SAUD) technique was used. In contrast to other deaggregation techniques, SAUD provides a properly improvement in quality of ND dispersion and this is reflected in the optimization of mechanical properties of cellulose acetate-nanodiamond (CA-ND) scaffolds. Results obtained after 2 and 5 days of osteoblastic-cell culture in our CA-ND scaffolds, showed good proliferation and no negative effects. Dynamic light scattering and scanning electron microscopy were used to characterize the average size of SAUD nanodiamonds and cell morphology, respectively. The obtained results, confirmed that CA-ND scaffolds could have potential applications on the biomedical field.

Applications of nanotechnology in bone tissue regeneration

255th National Meeting (2018)

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