The Long-range Research Initiative (LRI) of the American Chemistry Council (ACC) catalyzes research to improve toxicity evaluation methods and exposure science. The goal of the LRI is support collaborative research to actualize the power of 21st century technologies to improve chemical safety evaluation methods. As the paradigm for toxicity evaluation shifts away from laboratory animal intensive studies, tiered risk-based approaches are emerging that are rely on computational tools, read across and integrated approaches to testing and assessment. A number of proof of concept methods and strategies by the ACC LRI are helping to inform development and implementation of alternatives to vertebrate testing strategic plan that is mandated by the recent amendments to the US Toxic Substances Control Act. This presentation will highlight these risk-based case study projects, including computational methods incorporating the TTC, <i>in vitro</i> fit or purpose assays linked to IVIVE, and toxicogenomic biological profiling for read across.

Tiered risk-based safety evaluation for a 21<sup>st</sup> century TSCA

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Tiered risk-based safety evaluation for a 21st century TSCA

Tiered risk-based safety evaluation for a 21^st century TSCA