The goal of this research was to model the 3D drug release kinetics of a controlled drug release from a double-shell spherical nano-particle. The model is used to predict the diffusion coefficient and molecular flux of any drug released from spherical nanoparticle based on experimental data. Knowing the molecular flux will also allow for the quantitative model of the inner shell of the nanoparticle. Mass transport principles such as Fick’s Law and the continuity equation were applied to experimental data from an ongoing drug release study. The subsequent analysis investigated the flux of the drug particles over time, the change of concentration over radius of the sphere, and percentage of drug remaining. This computational study culminated in estimating the location of the inner shell and the limit of drug transport, which can be used to tailor the physical and chemical characteristics of nano-particles for controlled release and drug delivery.

Modeling molecular flux in nano-particle assisted drug deliver

255th National Meeting (2018)

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