Hydrogels are three-dimensional network structures obtained from a class of synthetic and/or natural polymers which can absorb and retain significant amount of water. The hydrogels have been used extensively in various biomedical applications such as drug delivery, cell carriers and/or entrapment, wound management and tissue engineering. Sacran is cyanobacterial-polysaccharide extracted from Aphanothece sacrum which contain 11 % of sulfate group, 22 % of carboxyl group and about 250 % of hydroxyl group to sugar residues. Moreover sacran has a very high molecular weight of 29 Mg/mol and then a super-absorbent property to induce an anti-inflammatory activity. We found that it can be prepared the physical hydrogel of sacran from the film which is made by cast-drying method. Concretely, the 0.5 % sacran solution was dried in oven at 60 oC for 12 h to create the thin film (about 50 mm), and the film was immersed into pure water to anisotropic hydrogels (this phenomenon was observed only in sacran not in another polysaccharide). It was additionally found that the swollen degree of the gels was controlled by the heating temperature treating precursor film ranging 60-140 oC. As a result, we controlled the swollen degree of the gels from 20 to 800 times to the dry weight depending on the heating temperature of the films. The following properties of the hydrogels were evaluated: water content, swelling ratio in water, gel strength, and then their structure was analyzed by FT-IR spectroscopy and X-ray analysis.

Preparation of anisotropic physical hydrogels of cyanobacterial super-polysaccharides

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.