The endoplasmic reticulum (ER) membrane protein complex (EMC) is associated with the endoplasmic-reticulum-associated protein degradation (ERAD) network, dengue virus propagation, lipid transport, and conjunction of the ER. Little is known about the role and structure of recently identified EMC subunit 9. Detailed structural information pertaining to EMC9 will aid our understanding of how these subunits collaborate with one another and the rest of the EMC complex to facilitate function. Further analysis could also provide useful information for the design of therapies for diseases caused by malfunctions in ERAD. Previous work produced a theoretical model of EMC9 structure; this model provides evidence supporting a potential homo-dimeric structure. This investigation examined the oligomerization state of the protein via analytical size exclusion chromatography. In addition, secondary structure content was determined through circular dichroism spectroscopy.<br/>

Structural investigations on ER membrane complex subunit 9

255th National Meeting (2018)

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