Small molecule fluorophores provide valuable tools for visualizing biological species. Fluorophores that absorb and emit light within the near-infrared (NIR) window are particularly desirable for monitoring biological events since NIR light has deeper tissue penetration and mitigates issues associated with autofluorescence of natively occurring fluorophores. We are endowing fluorophores with new chemical functionalities in order to obtain NIR reagents to probe biologically-relevant signaling molecules as well as new tools for perturbing living systems. Our recent efforts to measure and modulate biological processes using these new fluorophore scaffolds will be discussed.

New fluorophore scaffolds for chemical biology

255th National Meeting (2018)

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