New avenues in biomedical research are being discovered to aid in topical burn wound care and treatment. Electrospinning antibiotic-infused biodegradable nanofibers has arisen as a viable means of creating enhanced drug delivery. Silver has served as an antimicrobial agent for treating burn wounds. The incorporation of silver based antibiotics into nanofibers may serve as an agent to combat infection, as well as, a good vehicle for drug delivery. In order to test this possibility, solutions of hyaluronic acid (HA) and poly(ethylene oxide) (PEO) were mixed with silver sulfadiazine and spun using electrospinning to synthesize nanofibers. Different concentrations of antibiotic were tested to find the optimal concentration for significant inhibition of bacterial growth in both gram negative and gram positive bacteria. Findings may lead to economical and health benefits for those suffering from burn wounds.

Effect of silver-based antibiotic infused nanofibers on bacterial growth and drug delivery

255th National Meeting (2018)

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