Metformin Hydrochloride (MF) is one of the most widely prescribed drugs for the treatment of type 2 diabetes mellitus due to its ability to lower both basal and postprandial plasma blood glucose. Currently, two polymorphic crystal structures of MF exist, and the lattice structure of both forms has been studied extensively, as polymorphism is a major factor in active pharmaceutical ingredient determination. In this study, we are reporting for the first time the usage of Raman Under Nitrogen Spectroscopy (RUNS) on MF and its interactions with water. Probing the low energy modes of the MF crystal structure using RUNS will offer key insights into the vibrational frequency shifts arising from noncovalent interactions.

Spectroscopic and computational study of metformin hydrochloride utilizing Raman under nitrogen spectroscopy to examine lattice structure

255th National Meeting (2018)

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