An artificial nucleolipid containing thymine, triazole-ring, and phosphotidylcholine moieties(TTPC) was prepared through copper azide alkyne cycloaddition(CuAAC) in aqueous condition, and TTPCs in-situ assemble into fiberousaggregation. Our study of the TTPC fiber assembly using XRD and NMR reveals that theformation of fiber is driven by the unique molecular structure of TTPC. At a critical TTPC-concentration, entanglement of fibers results in a supramolecular hydrogel. The elaborated investigation of the lyotropic mesophases in TTPC supramolecular hydrogel shows the existence of abundant liquid crystalline phases including nematic, hexagonal,and lamellar phases, all of which have certain degree of structural order and are promising template for constructing functional biomaterials.

Supermolecular hydrogel prepared form thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophases

255th National Meeting (2018)

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