This poster will present the synthesis and characterization by Nuclear Magnetic Resonance (NMR) spectroscopy of a series of two new thiosemicarbazone molecules.  We have successfully synthesized the PPDO-TSC compounds using α-Isonitrosopropiophenone and an appropriate thiosemicarbazide.  These new molecules seem to exhibit different conformations depending upon the reaction conditions.  We have also successfully synthesized the INAP-TSC compounds using α-Isonitrosoacetophenone and an appropriate thiosemicarbazide.  This research has experimented with different reaction procedures in the hope of finding the cleanest and most efficient synthesis route.  Our use of NMR has enabled us to determine the most appropriate synthesis procedures to ensure the cleanest products.  After finding the best synthesis procedure, we have begun making new copper-complex molecules using these synthesized thiosemicarbazones.  New thiosemicarbazone ligands are important in designing new anti-cancer drugs, so this research is providing new molecules for testing against breast cancer cells in the future. <br/>

Synthesis and NMR analysis of PPDO-TSC and INAP-TSC compounds: Complexation to form their Cu(II) complexes

255th National Meeting (2018)

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