The cysteine perfluoroaryl S<sub>N</sub>Ar reaction has found applications in site-selective protein modification and peptide stapling. However, the chemical stability of this linker remains relatively unexplored. This presentation will discuss the oxidation and reduction chemistry of cysteine perfluoroaryl thioethers of both linear and cyclic peptides.<br/>

Selective reactions of cysteine perflouroaryl thioethers

255th National Meeting (2018)

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