Rhodamine derivatives are known to function as sensors and have shown promise for intra-cellular monitoring. Rhodamine can be present in an open form that is colored and fluorescent and a closed form that is non-colored and non-fluorescent. In its open form, there is an sp<sup>2, </sup>sp<sup>2 </sup>single bond that has limited rotation. Asymmetric rhodamine derivatives are atropisomers and have potential for applications related to chiral sensors and molecular switches. Herein, we have measured the rotational barrier for several atropisomeric rhodamine derivatives. This data will be compared to variations in structure of the derivatives measured in order to determine the relationship between the measured barrier and the structure. This data will help guide the formation of other derivatives that have specific applications related to sensing and switches.

Structural effects on the rotational barrier atropisomeric rhodamine derivative

255th National Meeting (2018)

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