Pyrrolizidine alkaloids (PA’s) are potentially toxic, naturally occurring, secondary products that are typically found in the plant family Boraginaceae. In this study, we examined garden grown populations of Arnebia pulchra, Lindelofia anchusioides, and Omphalodes verna to re-evaluate published literature results utilizing GC-MS and NMR instrumentation. Findings from the 1950’s and 1960’s of these plants demonstrated the presence of novel PA compounds, such as macrotomine and lindelofine. Each of these plants possess saturated pyrrolizidine alkaloids whose ring stereochemistry was proposed without the benefit of modern instrumentation. The current analysis will focus on NMR experimentation to ascertain the relative stereochemistry of these alkaloids.

Isolation of saturated pyrrolizidine alkaloids from Arnebia pulchra, Lindelofia anchusioides, and Omphalodes verna

255th National Meeting (2018)

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