The continuous monitoring of blood insulin levels would improve the treatment of type I diabetes by allowing us to fully optimize the administration of exogenous insulin.  Toward this end, we are developing a chemical sensor for insulin that is sufficiently sensitive and reversible to allow continuous use in a clinical setting.  Our approach is based on a synthetic receptor, which is sufficiently robust and non-toxic, and the current project aims to increase its affinity and selectivity for insulin to physiologically relevant levels.  The current state of our synthetic and physical-organic studies will be presented.<br/>

Structure activity studies of insulin recognition by cucurbit[7]uril

255th National Meeting (2018)

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