We report our ongoing efforts in the synthesis and evaluation of constrained medium-sized ring systems that place a donor atom in close proximity to a remote acceptor. The systems are evaluated via Natrual Bond Orbital (NBO) analysis, Perlin effects, and crystal structure when available. The stabilization energies range from 0.7kcal/mol to 1.5kcal/mol. Calculations also suggest the potential for anchieric assistance when a leaving group is positioned at the acceptor location.

Long-range donor-acceptor effects in heterocyclic medium-sized rings: Structural analysis, perlin effects, and anchimeric assistance

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.