The in situ synthesis of liposome-forming phospholipid in water provides a versatile tool for studying the dynamics and applications of artificial membranes. However, current methods for the de novo formation of vesicles rely on covalent static bonds which hampers the ability of the membrane to respond to the environment. In this communication we show how certain lysolipids are able to react with lipid tails in a dynamic fashion. This characteristic provides a way to distinguish between different lipidic tails, depending on the ability of the resulting phospholipids to form membranes. The dynamic system can also react to external stimuli and modify the properties of the resulting liposome.

In situ synthesis of dynamic phospholipid membranes

255th National Meeting (2018)

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