LpxC, an enzyme involved in the first committed step of the biosynthesis of lipid A, has been found to be a crucial drug target. This inhibition is critical for developing novel antibacterial treatments, especially with the growing resistance Gram-negative bacteria is having towards already developed treatments. Through the computational analysis of the crystal structure of LpxC, novel inhibitors have been designed to mimic the natural substrate of LpxC. The computational analysis and synthesis of these analogues, as well as their chemical stability and preliminary antibacterial activity, will be discussed.

Computational analysis and synthesis of potential inhibitors active against Gram-negative bacteria

255th National Meeting (2018)

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