To date, few cost-efficient syntheses of biologically and synthetically useful 1,3-amino alcohols exist. One potential heterodox synthetic pathway may be the employment of the three-component Mannich reaction, expending a ketone, an amine, and an aldehyde as constituents, a method for constructing C–C bonds. Utilizing a Knolker-type iron catalyst, a mild, redox-neutral Mannich-type synthesis of 1,3-amino alcohols from commercially available ketones, amines, and alcohols was investigated (<i>Figure 1</i>). Overall, the 3-step cascade was examined stepwise, enabling the optimization of reaction conditions, with emphasis on both the iron catalyst and solvent. As such, this new synthetic approach may prove to more conveniently offer a large scope of applicable 1,3 -amino alcohol compounds.

1,3-Amino alcohol synthesis via a catalytic 3-step cascade

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.