A primary interest in the Wooley laboratory is the production of functional polymers from renewable sources that are capable of reverting to those natural products once their purpose has been served. The inherent stereochemical and functional diversities of natural products provide opportunities to expand the scopes and complexities of polymer materials, by utilizing fundamental synthetic organic chemistry approaches. This presentation will highlight synthetic strategies for the development of polymer materials, which can be produced by relatively simple approaches from complex polyhydroxyl natural products and can be made to exhibit a range of properties, based upon the monomeric building blocks and, typically, carbonate or phosphoester linkages. A focus of this presentation will be on the transformation of D-glucose and other sugars into well-defined polymers with investigation of those materials as nanoscopic drug delivery devices in direct routes of administration for the treatment of osteosarcoma lung metastases or recurrent urinary tract infections.

Transformation of natural products into functional polymer systems, with guidance by biomedical application targets

255th National Meeting (2018)

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