Substrate pre-organization has dominated bio-inspired catalytic strategies using supramolecular capsule systems. The scarcity of capsule-catalyzed annulation reactions (A+B→C) highlights the limitation of this approach—while co-encapsulation gives high effective reactant concentration, product inhibition frequently halts turnover. In this talk two novel and distinct methods for realizing capsule-catalyzed annulation processes will be described, both involving the host-guest chemistry of simple Pd2L4 assemblies. .

Turning capsule catalysis inside out: Novel approaches utilizing innately-polarized Pd2L4 scaffolds

255th National Meeting (2018)

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