Clarification is the first downstream processing step of mammalian cell cultures and is typically performed using depth filtration for its robust linear scalability, ease-of-use and performance. The use of pre-treatment on the harvest can prove to be very beneficial in terms of contaminant clearance but is usually also challenging for the following depth filtration step. The study presented here shows the very high performance of a newly developed synthetic depth filter towards a pre-treated CHO culture expressing a mAb targeting Middle East respiratory syndrome.

Clarification of a pre-treated mAb-producing harvest using new fully synthetic depth filter technology

255th National Meeting (2018)

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