From the building blocks of nature to disease-battling pharmaceuticals carbohydrates have had deep impact on many aspects of science and technology. Numerous applications of these biomolecules exist, most of which can be found in the areas of functional-food, therapeutic-agent, and diagnostic-platform development. Although carbohydrates are desirable for the biomedical community, these molecules are very challenging synthetic targets. The development of practical and general methods for chemical glycosylation and oligosaccharide synthesis represent important areas of research.<br/><br/>At the core of this presentation is the development of a new concept for chemical glycosylation introduced by our laboratory. Discussed herein are our recent results on defining the scope of the regenerative glycosylation method and its application to the oligosaccharide assembly via conventional stepwise approach and HPLC-assisted automated synthesis.

Regenerative glycosylation via nucleophilic catalysis

255th National Meeting (2018)

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