Over production of reactive oxygen species (ROS) in metabolism is closely associated with many diseases. Hydroxyl radical, as the most reactive species among the ROS, has very short life time and extremely reactive. Thus, it is very challenging to selectively detect the hydroxyl radical. This presentation will describe the design and development of binary fluorescent nanodiamonds for detection of hydroxyl radicals based on use of GUMBOS (Group of Uniform Materials Based on Organic Salts). These nanoprobes are very sensitive to hydroxyl radicals as compared to other ROS. By use of the property of Förster resonance energy transfer (FRET) from these binary nanodiamonds, a ratiometric fluorescence profile for detection of hydroxyl radical is provided. Use of an in vitro study confirms the ability of these nanoprobes for detection of hydroxyl radicals in biological environments. The attributes of this novel sensor will be discussed in detail.

Ratiometric fluorescence nanoprobe for hydroxyl radical detection

255th National Meeting (2018)

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