Applications of continuous processing within pharma have expanded dramatically over the past decade. Many examples of hybrid batch / flow processes have been published, but relatively few examples of practical, scalable multi-step processes have been reported. Almost none have been reported under good manufacturing practices (GMP) within a commercial manufacturing facility. This talk will describe the design, development and scale up of multi-step continuous process under GMP conditions with focus on control strategy. This will include descriptions of reactions in CSTRs, PFRs, workup unit operations and continuous crystallization of API.

Fully continuous multi-step synthesis of drug substance under GMP conditions

255th National Meeting (2018)

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